IL28B rs12979860 Gene Polymorphism in Egyptian Patients with Chronic Liver Disease Infected with HCV

IL28B rs12979860 gene polymorphism in Egyptian patients with chronic liver disease infected with HCV.

BACKGROUND Egypt has one of the highest prevalences of hepatitis C virus (HCV) infection worldwide. Although the IL28B gene polymorphism has been shown to modify the course of chronic HCV infection, this has not been properly assessed in the Egyptian population. MATERIALS AND METHODS The IL28B rs12979860 single nucleotide polymorphism (SNP) was therefore examined in 256 HCV-infected Egyptian ...

Hepatopulmonary Syndrome in Egyptian Patients with HCV- Related Chronic Liver Disease

Background and Aim: Hepatopulmonary syndrome (HPS) is defined as the presence of liver disease in association with intrapulmonary vascular dilatation and arterial hypoxemia. This work aimed at evaluation of hepatopulmonary syndrome in Egyptian patients with HCV-related chronic liver disease. Patients and Methods: This cross-sectional study included sixty patients with HCV-related chronic liver ...

Impact of Interleukin-28B gene polymorphism (rs12979860) on Egyptian patients infected with hepatitis C virus genotype-4.

Single nucleotide polymorphisms (SNPs) in the Interleukin (IL)-28B gene, namely rs12979860, could predict response to pegylated interferon-α-ribavirin (PR) therapy in hepatitis C virus genotype 1 (HCV-1)-infected patients. A similar role was investigated in a case-control study conducted on 93 Egyptian patients chronically infected with HCV-4 in comparison to 22 individuals with spontaneous HCV...

Association of IL28B SNP With Progression of Egyptian HCV Genotype 4 Patients to End Stage Liver Disease

BACKGROUND IL28B single nucleotide polymorphisms (SNPs) play important roles in the management of hepatitis C virus (HCV) infections and are strongly associated with spontaneous and treatment-induced HCV clearance. OBJECTIVES In the present study, the association between IL28B variants and the progression of HCV infection in Egyptian patients infected with type 4a virus will be examined. PA...

association of il28b snp with progression of egyptian hcv genotype 4 patients to end stage liver disease